Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct and overlapping functional roles of Src family kinases in mouse platelets.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2012

Séverin S, Nash C A, Mori J, Zhao Y, Abram C, Lowell C A, Senis Y A, Watson S P

Abstract excerpt

BACKGROUND AND OBJECTIVES: Src family kinases (SFKs) play a critical role in initiating and propagating signals in platelets. The aims of this study were to quantitate SFK members present in platelets and to analyze their contribution to platelet regulation using glycoprotein VI (GPVI) and intreg...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Shape
Share to Fibrinogen
Share to Platelet Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Platelet Adhesiveness

Share to Platelet Glycoprotein GPIIb-IIIa Complex

Share to Platelet Membrane Glycoproteins

Share to Proto-Oncogene Proteins c-fyn

Share to src-Family Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 22694307
DOI: 10.1111/j.1538-7836.2012.04814.x
PMCID: PMC4280098

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22694307-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct and overlapping functional roles of Src family kinases in mouse platelets.PMID 22694307Read ↗

The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formationSemantic proximity Read ↗

Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets.Semantic proximity Read ↗

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.Semantic proximity Read ↗

Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets.Semantic proximity Read ↗

Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation.Semantic proximity Read ↗

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.Semantic proximity Read ↗

Reciprocal Signaling by Integrin and Nonintegrin Receptors during Collagen Activation of PlateletsSemantic proximity Read ↗

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen.Semantic proximity Read ↗

Contrasting Effects of Platelet GPVI Deletion versus Syk Inhibition on Mouse Jugular Vein Puncture Wound StructureSemantic proximity Read ↗

Thymidine phosphorylase participates in platelet signaling and promotes thrombosis.Semantic proximity Read ↗

Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis.Semantic proximity Read ↗

Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.