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Article

The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion

13 May 2003

Abstract excerpt

Platelet interaction with exposed adhesive ligands at sites of vascular injury is required to initiate a normal hemostatic response and may become a pathogenic factor in arterial diseases leading to thrombosis. We report a targeted disruption in a key receptor for collagen-induced platelet activation, glycoprotein (GP) VI. The breeding of mice with heterozygous GP VI alleles produced the expected frequency of...

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Share to Blood Coagulation and Thrombosis Mechanisms
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Identifiers

PMID: 12738669
DOI: 10.1182/blood-2003-03-0717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletionPMID 12738669Read ↗

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Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation.Semantic proximity Read ↗

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Contrasting Effects of Platelet GPVI Deletion versus Syk Inhibition on Mouse Jugular Vein Puncture Wound StructureSemantic proximity Read ↗

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