Article
The Novel Oral Syk Inhibitor, Bl1002494, Protects Mice From Arterial Thrombosis and Thromboinflammatory Brain Infarction.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016
van Eeuwijk Judith M M, Stegner David, Lamb David J, Kraft Peter, Beck Sarah, Thielmann Ina, Kiefer Friedemann, Walzog Barbara, Stoll Guido, Nieswandt Bernhard
Abstract excerpt
OBJECTIVE: Ischemic stroke, which is mainly caused by thromboembolic occlusion of brain arteries, is the second leading cause of death and disability worldwide with limited treatment options. The platelet collagen receptor glycoprotein VI (GPVI) is a key player in arterial thrombosis and a critical determinant of stroke outcome, making its signaling pathway an attractive target for pharmacological intervention....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.