Article
The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.
Nature communications - 17 Mar 2015
Mountford Jessica K, Petitjean Claire, Putra Harun W Kusuma, McCafferty Jonathan A, Setiabakti Natasha M, Lee Hannah, Tønnesen Lotte L, McFadyen James D, Schoenwaelder Simone M, Eckly Anita, Gachet Christian, Ellis Sarah, Voss Anne K, Dickins Ross A, Hamilton Justin R, Jackson Shaun P
Abstract excerpt
PI3KC2α is a broadly expressed lipid kinase with critical functions during embryonic development but poorly defined roles in adult physiology. Here we utilize multiple mouse genetic models to uncover a role for PI3KC2α in regulating the internal membrane reserve structure of megakaryocytes (demarcation membrane system) and platelets (open canalicular system) that results in dysregulated platelet adhesion under...
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