Article

Lack of canonical PAR4 activation is associated with reduced arterial and venous thrombosis in mice

2026-07-23

Abstract excerpt

<h4>Background</h4> Protease-activated receptor 4 (PAR4) is the only functional thrombin receptor on mouse platelets. Expression and activation of platelet PAR4 was shown to influence hemostatic plug stability and contributes to thrombosis in different murine arterial and venous thrombosis models. PAR4 activation by thrombin and other serine proteases occurs at the canonical activation site at Arginine (Arg) 59 i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a145dc1-dff7-52ed-8259-43afc2f6e949
DOI: 10.64898/2026.07.20.739624

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lack of canonical PAR4 activation is associated with reduced arterial and venous thrombosis in miceDOI 10.64898/2026.07.20.739624Read

A Mouse Model of the Protease Activated Receptor 4 (PAR4) Pro310Leu Variant has Reduced Platelet ReactivitySemantic proximity Read

A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity.Semantic proximity Read

Protection against thrombosis in mice lacking PAR3.Semantic proximity Read

Human PAR1 expressed on mouse platelets contributes to hemostasis and arterial occlusionSemantic proximity Read

Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets.Semantic proximity Read

Protease activated receptor-4: ready to be part of the antithrombosis spectrum.Semantic proximity Read

Mice with reduced protease-activated receptor 4 reactivity show decreased venous thrombosis and platelet procoagulant activity.Semantic proximity Read

Protection of β2GPI Deficient Mice from Thrombosis Reflects a Defect in PAR3-facilitated Platelet ActivationSemantic proximity Read

Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition.Semantic proximity Read

Protease-activated receptor 3 is a second thrombin receptor in humans.Semantic proximity Read

Sodium/Potassium ATPase Alpha 1 Subunit Fine-tunes Platelet GPCR Signaling Function and is Essential for ThrombosisSemantic proximity Read

A gain-of-function filamin A mutation in mouse platelets induces thrombus instability.Semantic proximity Read