Somatic mutation landscapes at single-molecule resolution.

doi:10.1038/s41586-021-03477-4

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Article

Somatic mutation landscapes at single-molecule resolution.

Nature - 1 May 2021

Abascal Federico, Harvey Luke M R, Mitchell Emily, Lawson Andrew R J, Lensing Stefanie V, Ellis Peter, Russell Andrew J C, Alcantara Raul E, Baez-Ortega Adrian, Wang Yichen, Kwa Eugene Jing, Lee-Six Henry, Cagan Alex, Coorens Tim H H, Chapman Michael Spencer, Olafsson Sigurgeir, Leonard Steven, Jones David, Machado Heather E, Davies Megan, Øbro Nina F, Mahubani Krishnaa T, Allinson Kieren, Gerstung Moritz, Saeb-Parsy Kourosh, Kent David G, Laurenti Elisa, Stratton Michael R, Rahbari Raheleh, Campbell Peter J, Osborne Robert J, Martincorena Iñigo

Abstract excerpt

Somatic mutations drive the development of cancer and may contribute to ageing and other diseases1,2. Despite their importance, the difficulty of detecting mutations that are only present in single cells or small clones has limited our knowledge of somatic mutagenesis to a minority of tissues. Here, to overcome these limitations, we developed nanorate sequencing (NanoSeq), a duplex sequencing protocol with error...

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PMID: 33911282
DOI: 10.1038/s41586-021-03477-4

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