Article

Assessing base-resolution DNA mechanics on the genome scale

2022-02-19

Abstract excerpt

Intrinsic DNA properties such as bending play a crucial role in diverse biological systems. A recent advantage in the high-throughput method called loop-seq makes it possible to determine bendability of hundred thousand 50-bp DNA duplexes in one experiment. However, it’s still infeasible to assess whole sequence bendability in large genomes such as human, which needs thousands of loop-seq experiments. Here we intr...

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Literature Corpus work: 588b9780-4d94-5ab6-b1aa-937c0ea0b719
DOI: 10.1101/2022.02.16.480786

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