Article

Hierarchical prediction and perturbation of chromatin organization reveal how loop domains mediate higher-order architectures

2025-05-29

Abstract excerpt

The genome is folded within the dense cell nucleus in a hierarchical manner, resulting in complex interactions between distinct folding strategies at various length scales. To elucidate how short-range loop domains regulate higher-order structures of the chromatin, such as topologically associating domains (TADs) and compartments, we introduce HiCGen, a hierarchical and cell-type-specific generator based on Swin-t...

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Literature Corpus work: 2353e8ce-7c8c-56f3-a153-9f67c21f6e6c
DOI: 10.1101/2025.05.25.656045

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