Article

DNA Mechanical Strain Steers Transcription Factor Recognition

2026-05-12

Abstract excerpt

<title>Abstract</title> <p>DNA is not merely a linear code of bases, but a mechanically constrained polymer whose backbone continuity restricts the conformations accessible during protein recognition. Yet, although base-sequence preferences have been extensively mapped across human transcription factor (TF) families, we lack comparable maps of how TFs read backbone continuity and DNA mechanics, leaving these laye...

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Literature Corpus work: 32ae4277-6a85-5e10-b07b-0c96d908013e
DOI: 10.21203/rs.3.rs-7027346/v1

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