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Germline genetic risk converges through intercellular crosstalk in tumor microenvironment

2025-10-17

Abstract excerpt

Germline genetic variation contributes to nasopharyngeal carcinoma (NPC) risk, but how susceptibility genes act across tumor microenvironment (TME) and whether enriched cell types interact remain unclear. Here we integrated large-scale NPC genetic association data(N=9,447) with transcriptomic datasets of NPC tumors, including single-cell RNA-seq(N=31), bulk RNA-seq(N=180) and spatial transcriptomics(N=7). We found...

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Literature Corpus work
6c2d29ad-aaba-56b5-aec6-2582b72d3f61
DOI
10.1101/2025.10.14.25337882
Open publication

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Germline genetic risk converges through intercellular crosstalk in tumor microenvironmentDOI 10.1101/2025.10.14.25337882
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