Whole-Exome Sequencing Study of Familial Nasopharyngeal Carcinoma and Its Implication for Identifying High-Risk Individuals.

doi:10.1093/jnci/djac177

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Article

Whole-Exome Sequencing Study of Familial Nasopharyngeal Carcinoma and Its Implication for Identifying High-Risk Individuals.

Journal of the National Cancer Institute - 8 Dec 2022

Wang Tong-Min, He Yong-Qiao, Xue Wen-Qiong, Zhang Jiang-Bo, Xia Yun-Fei, Deng Chang-Mi, Zhang Wen-Li, Xiao Ruo-Wen, Liao Ying, Yang Da-Wei, Zhou Ting, Li Dan-Hua, Luo Lu-Ting, Tong Xia-Ting, Wu Yan-Xia, Chen Xue-Yin, Li Xi-Zhao, Zhang Pei-Fen, Zheng Xiao-Hui, Zhang Shao-Dan, Hu Ye-Zhu, Wang Fang, Wu Zi-Yi, Zheng Mei-Qi, Huang Jing-Wen, Jia Yi-Jing, Yuan Lei-Lei, You Rui, Zhou Guan-Qun, Lu Li-Xia, Liu Yu-Ying, Chen Ming-Yuan, Feng Lin, Dai Wei, Ren Ze-Fang, Mai Hai-Qiang, Sun Ying, Ma Jun, Zheng Wei, Lung Maria Li, Jia Wei-Hua

Abstract excerpt

BACKGROUND: Nasopharyngeal carcinoma (NPC) is closely associated with genetic factors and Epstein-Barr virus infection, showing strong familial aggregation. Individuals with a family history suffer elevated NPC risk, requiring effective genetic counseling for risk stratification and individualized prevention. METHODS: We performed whole-exome sequencing on 502 familial NPC patients and 404 unaffected relatives...

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PMID: 36066420
DOI: 10.1093/jnci/djac177

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