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Article

Pan-cancer analysis of single-cell profiles with polygenic signals reveals genetic influences on tumor immunity across cancers.

Communications biology - 21 May 2026

Deng Chunyu, Li Ka, Ma Yunlong, Li Jingjing, Li Yu, Su Mu, Zhou Yijun, Zhang Yaru, Su Jianzhong, Zhang Yan

Abstract excerpt

Inherited genetic variation can weaken the ability of the immune system to detect and eliminate malignant cells, limiting the effectiveness of cancer immunotherapy. However, how germline polymorphisms shape the tumor immune microenvironment across cancers remains unclear. Here, we present a polygenic analysis framework that integrates single-cell RNA sequencing with GWAS summary statistics across 14 cancer types...

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Identifiers

PMID: 42168330
DOI: 10.1038/s42003-026-10158-3
PMCID: PMC13462604

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CST7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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