Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.

doi:10.1038/s41422-020-0374-x

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Article

Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.

Cell research - 1 Nov 2020

Chen Yu-Pei, Yin Jian-Hua, Li Wen-Fei, Li Han-Jie, Chen Dong-Ping, Zhang Cui-Juan, Lv Jia-Wei, Wang Ya-Qin, Li Xiao-Min, Li Jun-Yan, Zhang Pan-Pan, Li Ying-Qin, He Qing-Mei, Yang Xiao-Jing, Lei Yuan, Tang Ling-Long, Zhou Guan-Qun, Mao Yan-Ping, Wei Chen, Xiong Ke-Xu, Zhang Hong-Bo, Zhu Shi-Da, Hou Yong, Sun Ying, Dean Michael, Amit Ido, Wu Kui, Kuang Dong-Ming, Li Gui-Bo, Liu Na, Ma Jun

Abstract excerpt

Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with extremely skewed ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor microenvironment (TME) represents a promising therapeutic approach in NPC, highlighting an urgent need to deepen the understanding of the complex NPC TME. Here, we generated single-cell transcriptome profiles for 7581 malignant cells and...

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Identifiers

PMID: 32686767
DOI: 10.1038/s41422-020-0374-x
PMCID: PMC7784929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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