Whole-exome sequencing association study reveals genetic effects on tumor microenvironment components in nasopharyngeal carcinoma.

doi:10.1172/JCI182768

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Article

Whole-exome sequencing association study reveals genetic effects on tumor microenvironment components in nasopharyngeal carcinoma.

The Journal of clinical investigation - 2 Jan 2025

Zeng Yanni, Luo Chun-Ling, Lin Guo-Wang, Li Fugui, Bai Xiaomeng, Ko Josephine Mun-Yee, Xiong Lei, Liu Yang, He Shuai, Jiang Jia-Xin, Yan Wen-Xin, Ong Enya Hui Wen, Li Zheng, Zhou Ya-Qing, Zhou Yun-He, Xu An-Yi, Liu Shu-Qiang, Guo Yun-Miao, Chen Jie-Rong, Cheng Xi-Xi, Cao Yu-Lu, Yu Xia, Wu Biaohua, Wei Pan-Pan, Ruan Zhao-Hui, Chen Qiu-Yan, Tang Lin-Quan, McKay James D, Jia Wei-Hua, Mai Hai-Qiang, Lim Soon Thye, Liu Jian-Jun, Lin Dong-Xin, Khor Chiea Chuen, Chua Melvin Lee Kiang, Ji Mingfang, Lung Maria Li, Zeng Yi-Xin, Bei Jin-Xin

Abstract excerpt

Nasopharyngeal carcinoma (NPC) presents a substantial clinical challenge due to the limited understanding of its genetic underpinnings. Here we conduct the largest scale whole-exome sequencing association study of NPC to date, encompassing 6,969 NPC cases and 7,100 controls. We unveil 3 germline genetic variants linked to NPC susceptibility: a common rs2276868 in RPL14, a rare rs5361 in SELE, and a common...

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Epstein-Barr Virus Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exome Sequencing

Herpesvirus 4, Human

Nasopharyngeal Carcinoma

Nasopharyngeal Neoplasms

Neoplasm Proteins

Ribosomal Proteins

Tumor Microenvironment

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Identifiers

PMID: 39744943
DOI: 10.1172/JCI182768
PMCID: PMC11684818

Genes

RPL14
SELE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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