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Tumor immune microenvironment delineates progression trajectories of distinct nasopharyngeal carcinoma phenotypes

23 May 2025

Abstract excerpt

We investigate the molecular landscape of locally advanced nasopharyngeal carcinoma (LA-NPC) subtypes: limited (L), ascending (A), descending (D), and ascending-descending (AD). Using a cohort of 994 patients, we perform germline and somatic whole-exome sequencing (WES), transcriptomic profiling, multiplex immunohistochemistry (mIHC), and spatial histopathological analyses of tumor whole-slide images (WSIs)....

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PMID: 40412382
DOI: 10.1016/j.xcrm.2025.102143

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