Article
Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma.
Nature communications - 9 Mar 2021
Gong Lanqi, Kwong Dora Lai-Wan, Dai Wei, Wu Pingan, Li Shanshan, Yan Qian, Zhang Yu, Zhang Baifeng, Fang Xiaona, Liu Li, Luo Min, Liu Beilei, Chow Larry Ka-Yue, Chen Qingyun, Huang Jinlin, Lee Victor Ho-Fun, Lam Ka-On, Lo Anthony Wing-Ip, Chen Zhiwei, Wang Yan, Lee Anne Wing-Mui, Guan Xin-Yuan
Abstract excerpt
The tumor microenvironment (TME) of nasopharyngeal carcinoma (NPC) harbors a heterogeneous and dynamic stromal population. A comprehensive understanding of this tumor-specific ecosystem is necessary to enhance cancer diagnosis, therapeutics, and prognosis. However, recent advances based on bulk RNA sequencing remain insufficient to construct an in-depth landscape of infiltrating stromal cells in NPC. Here we...
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