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Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis.

Nature communications - 20 Jun 2023

Sato Go, Shirai Yuya, Namba Shinichi, Edahiro Ryuya, Sonehara Kyuto, Hata Tsuyoshi, Uemura Mamoru, Matsuda Koichi, Doki Yuichiro, Eguchi Hidetoshi, Okada Yukinori

Abstract excerpt

Integrating genomic data of multiple cancers allows de novo cancer grouping and elucidating the shared genetic basis across cancers. Here, we conduct the pan-cancer and cross-population genome-wide association study (GWAS) meta-analysis and replication studies on 13 cancers including 250,015 East Asians (Biobank Japan) and 377,441 Europeans (UK Biobank). We identify ten cancer risk variants including five...

Topics

Male
Humans
Genome-Wide Association Study
Genetic Predisposition to Disease
Prostatic Neoplasms
Breast Neoplasms
Carcinogenesis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37340002
DOI: 10.1038/s41467-023-39136-7
PMCID: PMC10282036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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