Article

Large-Scale Whole-Exome Sequencing Association Study Implicates Genetic Effects on Viral Oncogenesis and Tumor Microenvironment in Nasopharyngeal Carcinoma

2023-10-24

Abstract excerpt

Nasopharyngeal carcinoma (NPC) poses a substantial clinical challenge with limited understanding of its genetic underpinnings. Here we conduct the largest-scale whole-exome sequencing association study of NPC to date, involving 6,969 NPC cases and 7,100 controls and revealing three novel germline genetic variants linked to NPC susceptibility: a common variant rs2276868 in RPL14 , a rare variant rs5361 in SELE , an...

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Literature Corpus work: 68f328da-0c3c-50be-9356-b46205458a28
DOI: 10.1101/2023.10.18.23297131

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