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Integrative Analysis of GWAS and Single-Cell eQTL Data Identifies Immune Cell-Type-Specific Genetic Signals Co-occurring in Inflammatory Diseases and Lung Cancer Risk

2025-10-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Non-small cell lung cancer (NSCLC) frequently co-occurs with chronic inflammatory conditions such as COPD, RA, IPF, psoriasis, and Dermatomyositis. While epidemiological links are established, the genetic basis of this co-occurrence in specific cell types remains poorly resolved. <h4>Methods</h4> We applied a signal-driven colocalization approach to NSCLC GWAS index variant...

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Literature Corpus work: 7d8b5f85-5dde-5ad5-b06c-ba1a88a3aada
DOI: 10.1101/2025.10.04.25337327

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