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TNFSF8 Drives Oral Squamous Cell Carcinoma Progression via CD8+ T Cell Regulation: Insights from Multi-Omics Integration and Single-Cell eQTL Analysis

2025-08-11

Abstract excerpt

<title>Abstract</title> <p>Background Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy with limited therapeutic options. This study aimed to investigate the causal role of TNFSF8 in the progression of OSCC through multi-omics integration. Methods Cis-pQTL data from deCODE and the UK Biobank Plasma Proteomics Project (UKB-PPP) were used to perform two-sample Mendelian randomization (MR) analys...

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Literature Corpus work
3946a00b-975a-5d5e-b031-fef9292596ce
DOI
10.21203/rs.3.rs-7101139/v1
Open publication

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TNFSF8 Drives Oral Squamous Cell Carcinoma Progression via CD8+ T Cell Regulation: Insights from Multi-Omics Integration and Single-Cell eQTL AnalysisDOI 10.21203/rs.3.rs-7101139/v1
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