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Article

BnpC: Bayesian non-parametric clustering of single-cell mutation profiles.

Bioinformatics (Oxford, England) - 8 Dec 2020

Borgsmüller Nico, Bonet Jose, Marass Francesco, Gonzalez-Perez Abel, Lopez-Bigas Nuria, Beerenwinkel Niko

Abstract excerpt

MOTIVATION: The high resolution of single-cell DNA sequencing (scDNA-seq) offers great potential to resolve intratumor heterogeneity (ITH) by distinguishing clonal populations based on their mutation profiles. However, the increasing size of scDNA-seq datasets and technical limitations, such as high error rates and a large proportion of missing values, complicate this task and limit the applicability of existing...

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PMID: 32592465
DOI: 10.1093/bioinformatics/btaa599
PMCID: PMC7750970

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