Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing.

doi:10.1016/j.cell.2019.10.026

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Article

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing.

Cell - 14 Nov 2019

Laks Emma, McPherson Andrew, Zahn Hans, Lai Daniel, Steif Adi, Brimhall Jazmine, Biele Justina, Wang Beixi, Masud Tehmina, Ting Jerome, Grewal Diljot, Nielsen Cydney, Leung Samantha, Bojilova Viktoria, Smith Maia, Golovko Oleg, Poon Steven, Eirew Peter, Kabeer Farhia, Ruiz de Algara Teresa, Lee So Ra, Taghiyar M Jafar, Huebner Curtis, Ngo Jessica, Chan Tim, Vatrt-Watts Spencer, Walters Pascale, Abrar Nafis, Chan Sophia, Wiens Matt, Martin Lauren, Scott R Wilder, Underhill T Michael, Chavez Elizabeth, Steidl Christian, Da Costa Daniel, Ma Yussanne, Coope Robin J N, Corbett Richard, Pleasance Stephen, Moore Richard, Mungall Andrew J, Mar Colin, Cafferty Fergus, Gelmon Karen, Chia Stephen, Marra Marco A, Hansen Carl, Shah Sohrab P, Aparicio Samuel

Abstract excerpt

Accurate measurement of clonal genotypes, mutational processes, and replication states from individual tumor-cell genomes will facilitate improved understanding of tumor evolution. We have developed DLP+, a scalable single-cell whole-genome sequencing platform implemented using commodity instruments, image-based object recognition, and open source computational methods. Using DLP+, we have generated a resource of...

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Identifiers

PMID: 31730858
DOI: 10.1016/j.cell.2019.10.026
PMCID: PMC6912164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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