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Article

Identifying tumor clones in sparse single-cell mutation data.

Bioinformatics (Oxford, England) - 1 Jul 2020

Myers Matthew A, Zaccaria Simone, Raphael Benjamin J

Abstract excerpt

MOTIVATION: Recent single-cell DNA sequencing technologies enable whole-genome sequencing of hundreds to thousands of individual cells. However, these technologies have ultra-low sequencing coverage (<0.5× per cell) which has limited their use to the analysis of large copy-number aberrations (CNAs) in individual cells. While CNAs are useful markers in cancer studies, single-nucleotide mutations are equally...

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PMID: 32657385
DOI: 10.1093/bioinformatics/btaa449
PMCID: PMC7355247

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