Article

Haplotype-enhanced inference of somatic copy number profiles from single-cell transcriptomes

2022-02-10

Abstract excerpt

Genome instability and aberrant alterations of transcriptional programs both play important roles in cancer. However, their relationship and relative contribution to tumor evolution and therapy resistance are not well-understood. Single-cell RNA sequencing (scRNA-seq) has the potential to investigate both genetic and non-genetic sources of tumor heterogeneity in a single assay. Here we present a computational meth...

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Literature Corpus work: 6b604533-4b7b-575d-bf0b-3e8354d594e6
DOI: 10.1101/2022.02.07.479314

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