Article

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

2022-03-16

Abstract excerpt

<h4>ABSTRACT</h4> Experimental inactivation of certain genes involved in metabolism attenuates cancer cell growth in vitro . However, loss-of-function mutations in metabolic pathways are not negatively selected in human cancers, indicating that these genes are not essential in vivo . We hypothesize that spontaneous mutations affecting metabolic pathways do not necessarily result in a functional defect because a...

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Literature Corpus work: 6c0f8699-608f-548b-a403-3803ec05027b
DOI: 10.1101/2022.03.15.484462

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