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The genetic interaction map of the human solute carrier superfamily

12 May 2025

Abstract excerpt

Solute carriers (SLCs), the largest superfamily of transporter proteins in humans with about 450 members, control the movement of molecules across membranes. A typical human cell expresses over 200 different SLCs, yet their collective influence on cell phenotypes is not well understood due to overlapping substrate specificities and expression patterns. To address this, we performed systematic pairwise gene double...

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PMID: 40355755
DOI: 10.1038/s44320-025-00105-5

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