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Article

Gap junctions and cancer: communicating for 50 years.

Nature reviews. Cancer - 1 Dec 2016

Aasen Trond, Mesnil Marc, Naus Christian C, Lampe Paul D, Laird Dale W

Abstract excerpt

Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis that loss of direct intercellular communication is commonly associated with cancer onset and progression. Subsequent studies linked this phenomenon to gap junctions composed of connexin proteins. Although many studies support the notion that connexins are tumour suppressors, recent evidence suggests that, in some...

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Identifiers

PMID: 27782134
DOI: 10.1038/nrc.2016.105
PMCID: PMC5279857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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