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Article

Exploring the role of stromal osmoregulation in cancer and disease using executable modelling.

Nature communications - 1 Aug 2018

Shorthouse David, Riedel Angela, Kerr Emma, Pedro Luisa, Bihary Dóra, Samarajiwa Shamith, Martins Carla P, Shields Jacqueline, Hall Benjamin A

Abstract excerpt

Osmotic regulation is a vital homoeostatic process in all cells and tissues. Cells initially respond to osmotic stresses by activating transmembrane transport proteins to move osmotically active ions. Disruption of ion and water transport is frequently observed in cellular transformations such as cancer. We report that genes involved in membrane transport are significantly deregulated in many cancers, and that...

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Identifiers

PMID: 30069015
DOI: 10.1038/s41467-018-05414-y
PMCID: PMC6070494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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