Article
Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes.
eLife - 15 Sept 2022
Monterisi Stefania, Michl Johanna, Hulikova Alzbeta, Koth Jana, Bridges Esther M, Hill Amaryllis E, Abdullayeva Gulnar, Bodmer Walter F, Swietach Pawel
Abstract excerpt
Growth of cancer cells in vitro can be attenuated by genetically inactivating selected metabolic pathways. However, loss-of-function mutations in metabolic pathways are not negatively selected in human cancers, indicating that these genes are not essential in vivo. We hypothesize that spontaneous mutations in 'metabolic genes' will not necessarily produce functional defects because mutation-bearing cells may be...
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