Article

A unified model of amino acid homeostasis in mammalian cells

2021-02-09

Abstract excerpt

Homeostasis is one of the fundamental concepts in physiology. Despite remarkable progress in our molecular understanding of amino acid transport, metabolism and signalling, it remains unclear by what mechanisms cytosolic amino acid concentrations are maintained. We propose that amino acid transporters are the primary determinants of intracellular amino acid levels. We show that a cell’s endowment with amino acid t...

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Literature Corpus work: fd17bac2-c783-5317-b72f-afb4cb9b6b9e
DOI: 10.1101/2021.02.08.430327

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