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Article

Dominant cataracts result from incongruous mixing of wild-type lens connexins.

The Journal of cell biology - 9 Jun 2003

Martinez-Wittinghan Francisco J, Sellitto Caterina, Li Leping, Gong Xiaohua, Brink Peter R, Mathias Richard T, White Thomas W

Abstract excerpt

Gap junctions are composed of proteins called connexins (Cx) and facilitate both ionic and biochemical modes of intercellular communication. In the lens, Cx46 and Cx50 provide the gap junctional coupling needed for homeostasis and growth. In mice, deletion of Cx46 produced severe cataracts, whereas knockout of Cx50 resulted in significantly reduced lens growth and milder cataracts. Genetic replacement of Cx50...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12782682
DOI: 10.1083/jcb.200303068
PMCID: PMC2172970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dominant cataracts result from incongruous mixing of wild-type lens connexins.PMID 12782682Read ↗

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Identification of GJA3 p.S50P Mutation in a Chinese Family with Autosomal Dominant Congenital Cataract and Its Underlying Pathogenesis.Semantic proximity Read ↗

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