Article
Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null mice.
PloS one - 1 Jan 2008
Chang Qing, Tang Wenxue, Ahmad Shoeb, Zhou Binfei, Lin Xi
Abstract excerpt
Connexin26 (Cx26) and connexin30 (Cx30) are two major protein subunits that co-assemble to form gap junctions (GJs) in the cochlea. Mutations in either one of them are the major cause of non-syndromic prelingual deafness in humans. Because the mechanisms of cochlear pathogenesis caused by Cx mutations are unclear, we investigated effects of Cx30 null mutation on GJ-mediated ionic and metabolic coupling in the...
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