Article
The structural context of disease-causing mutations in gap junctions.
The Journal of biological chemistry - 29 Sept 2006
Fleishman Sarel J, Sabag Adi D, Ophir Eran, Avraham Karen B, Ben-Tal Nir
Abstract excerpt
Gap junctions form intercellular channels that mediate metabolic and electrical signaling between neighboring cells in a tissue. Lack of an atomic resolution structure of the gap junction has made it difficult to identify interactions that stabilize its transmembrane domain. Using a recently computed model of this domain, which specifies the locations of each amino acid, we postulated the existence of several...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.