Article

Opposing modulation of Cx26 gap junctions and hemichannels by CO <sub>2</sub>

2019-03-21

Abstract excerpt

<h4>Summary</h4> Cx26 hemichannels open in response to moderate elevations of CO 2 (PCO 2 55 mmHg) via a carbamylation reaction that depends on residues K125 and R104. Here we investigate the action of CO 2 on Cx26 gap junctions. Using a dye transfer assay, we found that an elevated PCO 2 of 55 mmHg greatly delayed the permeation of a fluorescent glucose analogue (NBDG) between HeLa cells coupled by Cx26 gap...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 190b2d0b-4e6a-536b-b2ee-244536f6e0a5
DOI: 10.1101/584722

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Opposing modulation of Cx26 gap junctions and hemichannels by CO <sub>2</sub>DOI 10.1101/584722Read

Connexin26 hemichannels with a mutation that causes KID syndrome in humans lack sensitivity to CO2.Semantic proximity Read

Altered CO2 sensitivity of connexin26 mutant hemichannels in vitro.Semantic proximity Read

Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO2.Semantic proximity Read

Rational design of new NO and redox sensitivity into connexin26 hemichannels.Semantic proximity Read

Mechanism of CO <sub>2</sub> and NH <sub>3</sub> Transport through Human Aquaporin 1: Evidence for Parallel CO <sub>2</sub> PathwaysSemantic proximity Read

Chimeric evidence for a role of the connexin cytoplasmic loop in gap junction channel gating.Semantic proximity Read

Cell-to-cell signalling mediated via CO <sub>2</sub> : activity dependent axonal CO <sub>2</sub> production opens Cx32 in the Schwann cell paranodeSemantic proximity Read

Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule.Semantic proximity Read

Control of intracellular pH and bicarbonate by CO2 diffusion into human spermSemantic proximity Read

Is the chemical gate of connexins voltage sensitive? Behavior of Cx32 wild-type and mutant channels.Semantic proximity Read

Zebrafish and mouse TASK-2 K(+) channels are inhibited by increased CO2 and intracellular acidification.Semantic proximity Read

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genesSemantic proximity Read