Article

Scalable context-dependent single-cell eQTL mapping reveals disease-relevant regulatory variation beyond static models

2026-08-14

Abstract excerpt

Many disease-associated variants are thought to act through gene regulation, yet conventional eQTL mapping explains only a fraction of GWAS loci, potentially because regulatory effects vary across cellular states and environments. We present CASTIE, a scalable Poisson mixed-model framework that directly models sparse single-cell read counts and enables genome-wide testing of genotype-by-context interactions withou...

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Literature Corpus work: a9f8ddeb-d16a-5968-b8c5-67121c38330d
DOI: 10.64898/2026.08.13.26360300

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