Article

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles

2022-11-01

Abstract excerpt

Translating genome-wide association study (GWAS) loci into causal variants and genes requires accurate cell-type-specific enhancer-gene maps from disease-relevant tissues. Building enhancer-gene maps is essential but challenging with current experimental methods in primary human tissues. We developed a new non-parametric statistical method, SCENT (Single-Cell ENhancer Target gene mapping) which models association...

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Literature Corpus work: 731e95f9-2606-5854-8ab9-55c3f465be06
DOI: 10.1101/2022.10.27.22281574

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