Leveraging cell-type specificity and similarity improves single-cell eQTL fine-mapping.

Abstract excerpt

Identifying cell-type-specific eQTL is important to understand the genetic regulation of gene expressions at the cell-type level and its relevance to complex traits. However, existing eQTL fine-mapping methods are limited in power and accuracy when cell types are analyzed separately. To improve eQTL mapping, we present CASE, a Bayesian framework to perform cell-type-specific and shared eQTL fine-mapping that...

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