Article

Multi-context genetic modeling of transcriptional regulation resolves novel disease loci

2021-09-23

Abstract excerpt

A majority of the variants identified in genome-wide association studies fall in non-coding regions of the genome, indicating their mechanism of impact is mediated via gene expression. Leveraging this hypothesis, transcriptome-wide association studies (TWAS) have assisted in both the interpretation and discovery of additional genes associated with complex traits. However, existing methods for conducting TWAS do no...

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Literature Corpus work: 544e534d-30fb-5ff4-930e-9611eeb036e1
DOI: 10.1101/2021.09.23.461579

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