Article

Efficient genome-wide mapping of reproducible, context-dependent eQTLs at single-cell resolution

2026-08-29

Abstract excerpt

Single-cell technologies enable linking disease-risk variants to gene regulatory effects in specific cell-state contexts. However, most so called "single-cell eQTL" studies use a "pseudobulking" strategy to identify expression Quantitative Trait Loci (eQTLs), obscuring subtle dynamic regulatory effects of disease alleles. Here, we propose Dynema (Dynamic eQTL mapping in single cells) for fast and accurate genome-w...

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Literature Corpus work: f39455a3-ec70-579f-b6c8-991b77d5ad5e
DOI: 10.64898/2026.08.25.747138

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