Beyond the baseline: mapping the context-specific regulatory landscape of disease.

Abstract excerpt

Genome-wide association studies have identified thousands of intergenic variants associated with disease, most of which are presumed to act by affecting gene regulation. Standard expression quantitative trait locus (eQTL) studies were able to link many disease-associated loci to changes in gene expression. Yet, many disease-associated loci show no detectable regulatory effects in baseline bulk gene expression...

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