Article

Unbiased identification of unknown cellular and environmental factors that mediate eQTLs using principal interaction component analysis

2022-07-30

Abstract excerpt

Expression quantitative trait loci (eQTL) can reveal the regulatory mechanisms of trait associated variants. eQTLs are highly cell-type and context-specific, but often these contexts are unknown or not measured. Here, we introduce PICALO (Principal Interaction Component Analysis through Likelihood Optimization), an unbiased method to identify known and hidden contexts that influence eQTLs. PICALO uses expectation...

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Literature Corpus work: cdd0e362-d476-5396-b82d-b029cf518d37
DOI: 10.1101/2022.07.28.501849

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