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Article

Multi-context genetic modeling of transcriptional regulation resolves novel disease loci.

Nature communications - 28 Sept 2022

Thompson Mike, Gordon Mary Grace, Lu Andrew, Tandon Anchit, Halperin Eran, Gusev Alexander, Ye Chun Jimmie, Balliu Brunilda, Zaitlen Noah

Abstract excerpt

A majority of the variants identified in genome-wide association studies fall in non-coding regions of the genome, indicating their mechanism of impact is mediated via gene expression. Leveraging this hypothesis, transcriptome-wide association studies (TWAS) have assisted in both the interpretation and discovery of additional genes associated with complex traits. However, existing methods for conducting TWAS do...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36171194
DOI: 10.1038/s41467-022-33212-0
PMCID: PMC9519579

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