Article

Single-cell lineage tracing maps clonal and transcriptional dynamics in melanoma metastasis

2026-04-13

Abstract excerpt

Melanoma metastasis is driven by extensive intratumoral heterogeneity and phenotypic plasticity, yet how clonal identity relates to transcriptional programs during metastasis remains unclear. Here, we applied MeRLin, a single-cell lineage tracing platform, to dissect the clonal and transcriptional heterogeneity of metastatic melanoma in a patient-derived spontaneous metastasis model. Clonal analyses revealed hiera...

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Literature Corpus work: 6bc7e432-1506-5cf7-b90e-1695a309b969
DOI: 10.64898/2026.04.09.717571

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