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Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses

8 Dec 2023

Abstract excerpt

Abstract Acral melanoma (AM) is a rare subtype of melanoma characterized by a high incidence of lymph node (LN) metastasis, a critical factor in tumor dissemination and therapeutic decision-making. Here, we employ single-cell and spatial transcriptomic analyses to investigate the dynamic evolution of early AM dissemination. Our findings reveal substantial inter- and intra-tumor heterogeneity in AM, alongside a...

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PMID: 38065972
DOI: 10.1038/s41467-023-43980-y

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