A cellular hierarchy in melanoma uncouples growth and metastasis.

doi:10.1038/s41586-022-05242-7

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Article

A cellular hierarchy in melanoma uncouples growth and metastasis.

Nature - 1 Oct 2022

Karras Panagiotis, Bordeu Ignacio, Pozniak Joanna, Nowosad Ada, Pazzi Cecilia, Van Raemdonck Nina, Landeloos Ewout, Van Herck Yannick, Pedri Dennis, Bervoets Greet, Makhzami Samira, Khoo Jia Hui, Pavie Benjamin, Lamote Jochen, Marin-Bejar Oskar, Dewaele Michael, Liang Han, Zhang Xingju, Hua Yichao, Wouters Jasper, Browaeys Robin, Bergers Gabriele, Saeys Yvan, Bosisio Francesca, van den Oord Joost, Lambrechts Diether, Rustgi Anil K, Bechter Oliver, Blanpain Cedric, Simons Benjamin D, Rambow Florian, Marine Jean-Christophe

Abstract excerpt

Although melanoma is notorious for its high degree of heterogeneity and plasticity1,2, the origin and magnitude of cell-state diversity remains poorly understood. Equally, it is unclear whether growth and metastatic dissemination are supported by overlapping or distinct melanoma subpopulations. Here, by combining mouse genetics, single-cell and spatial transcriptomics, lineage tracing and quantitative modelling,...

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Identifiers

PMID: 36131018
DOI: 10.1038/s41586-022-05242-7
PMCID: PMC10439739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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