Article

Clonal dynamics shaped by diverse drug-tolerant persister states in melanoma resistance

2025-09-19

Abstract excerpt

Most advanced melanomas initially respond to targeted therapy but eventually relapse. Rather than acquiring new mutations, resistance is driven by drug-tolerant persister cells that enter a reversible drug-refractory state. We developed MeRLin, a high-resolution lineage tracing platform integrating cellular barcoding, single-cell transcriptomics, RNA fluorescence in situ hybridization (FISH), and computational ana...

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Literature Corpus work: 19aa6ec6-b53c-536b-81b8-9396647517d4
DOI: 10.1101/2025.09.16.676608

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