Article

A comprehensive single cell atlas of healthy ocular tissue and uveal melanoma reveals mutation- and uveal tract-associated cell states

2026-04-29

Abstract excerpt

<title>Abstract</title> <p>Uveal melanoma is a rare but aggressive intraocular malignancy with limited therapeutic options and a high risk of metastatic relapse. Although its mutational landscape is well defined, how genetic factors, uveal location, and disease progression shape cell states and the tumor ecosystem remains poorly understood. We integrate single-cell RNA sequencing and spatial transcriptomics acros...

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Literature Corpus work: e08b61af-1c1c-51bb-a2a5-875ef3ed4e4e
DOI: 10.21203/rs.3.rs-9503349/v1

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