Article

Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT states

2020-08-12

Abstract excerpt

Metastatic cancer remains largely incurable due to an incomplete understanding of how cancer cells disseminate throughout the body. However, tools for probing metastatic dissemination and associated molecular changes at high resolution are lacking. Here we present multiplexed, activatable, clonal, and subclonal GESTALT (macsGESTALT), an inducible lineage recorder with concurrent single cell readout of transcriptio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f3b00205-6132-5f17-a0f4-829cc93aff54
DOI: 10.1101/2020.08.11.245787

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT statesDOI 10.1101/2020.08.11.245787Read

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts.Semantic proximity Read

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenograftsSemantic proximity Read

Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolutionSemantic proximity Read

Genetic barcoding of individual cells links cancer evolutionary trajectories and prognostic outcomesSemantic proximity Read

Mitochondrial clone tracing within spatially intact human tissuesSemantic proximity Read

High-resolution spatial mapping of cell state and lineage dynamics <i>in vivo</i> with PEtracerSemantic proximity Read

Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT statesSemantic proximity Read

Molecular Profiling and High-Content Drug Screening of Metastatic Colorectal Cancer Organoids Reveal Evolutionary Mechanisms of Pan-KRAS Inhibitor ResistanceSemantic proximity Read

Detection of Somatic Point Mutations Directly from Spatial Transcriptomics Enables in vivo Spatiotemporal Lineage TracingSemantic proximity Read

Single-cell lineage tracing maps clonal and transcriptional dynamics in melanoma metastasisSemantic proximity Read

Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analysesSemantic proximity Read

SunCatcher: Clonal Barcoding with qPCR-Based Detection Enables Functional Analysis of Live Cells and Generation of Custom Combinations of Cells for Research and DiscoverySemantic proximity Read