Article

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts

2020-04-17

Abstract excerpt

Cancer progression is characterized by rare, transient events which are nonetheless highly consequential to disease etiology and mortality. Detailed cell phylogenies can recount the history and chronology of these critical events – including metastatic seeding. Here, we applied our Cas9-based lineage tracer to study the subclonal dynamics of metastasis in a lung cancer xenograft mouse model, revealing the underlyi...

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Identifiers and source

Literature Corpus work: eb868c25-c12e-5066-b9e8-c57f29533c22
DOI: 10.1101/2020.04.16.045245

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