Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts.

doi:10.1126/science.abc1944

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Article

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts.

Science (New York, N.Y.) - 26 Feb 2021

Quinn Jeffrey J, Jones Matthew G, Okimoto Ross A, Nanjo Shigeki, Chan Michelle M, Yosef Nir, Bivona Trever G, Weissman Jonathan S

Abstract excerpt

Detailed phylogenies of tumor populations can recount the history and chronology of critical events during cancer progression, such as metastatic dissemination. We applied a Cas9-based, single-cell lineage tracer to study the rates, routes, and drivers of metastasis in a lung cancer xenograft mouse model. We report deeply resolved phylogenies for tens of thousands of cancer cells traced over months of growth and...

Topics

Animals
CRISPR-Cas Systems
Cell Line, Tumor
Cell Lineage
Clone Cells
Gene Expression Regulation, Neoplastic
Humans
Keratin-17
Lung Neoplasms
Mice
Neoplasm Invasiveness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

Neoplasm Seeding

Neoplasm Transplantation

Phenotype

RNA-Seq

Single-Cell Analysis

Transcriptome

Source

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Identifiers

PMID: 33479121
DOI: 10.1126/science.abc1944
PMCID: PMC7983364

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